The present study included 25 Type-1 diabetic patients (without complication) and 50 age-matched normal healthy controls who volunteered. reported that fibrinogen synthesis is inhibited by the administration of insulin, hyper fibrinogenemia associated with insulinopemia. Fibrinogen is an important determinant of blood viscosity that results from Fibrinogen-induced erythrocyte aggregation and its contribution to plasma viscosity. Fibrinogen is a risk factor for atherothrombiotic disease. (1996) reported a normal susceptibility of LDL to in vitro oxidation in well-controlled Insulin dependent Diabetes Mellitus (IDDM) patients.īlood and plasma viscosity have emerged as independent risk factors for atherothromobtic vascular disease. reported that MDA is the most commonly used marker of lipid peroxidation in diabetes mellitus.
Blood viscosity free#
The hyperglycemia or dyslipidaemia easily induce serious oxidative stress that causes serious cellular dysfunction as well as hematic and vascular complications in diabetic patients., Persistent hyperglycemia causes increased production of free radicals, especially reactive oxygen species (ROS), for all tissues from glucose auto-oxidation and protein glycosylation. Improved metabolic control may decrease very-low-density lipoprotein cholesterol (VLDL-Cholesterol) and low-density lipoprotein cholesterol (LDL-Cholesterol). The key features of this diabetic dyslipidaemia are elevated level of triglyceride and LDL-c. Dyslipidaemia is a common feature of diabetes even with good glycemic control. Insulin is the key hormone in blood glucose homeostasis. Diabetes mellitus is a common metabolic disorder resulting from defects in iInsulin secretion or action or both, which is characterized by hyperglycemia often accompanied by glycosuria, polydipsia, and polyuria resulting from an absolute or relative deficiency of insulin secretion or action.
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